Alprazolam has sedative, anticonvulsant and relaxant properties which help to calm a person down. What makes it even more popular is that the drug kicks into action almost immediately after consumption. However, some experts think that the human body adjusts to the effects of the drug very soon and therefore, the drug loses its effectiveness with long-term use.

Doctors recommend small doses of alprazolam for short-term treatment of panic disorder, and that of acute anxiety, together with associated depression, although it has not yet been verified if the drug indeed has antidepressant properties- but even if it does, the drug is a lot weaker medication for treating depression than other antidepressants.

Xanax is marketed in the US in the form of liquids, and tablets, including orally dissolving tablets. The available strengths of Xanax tablets covers a range of 0.25 mg to 2mg. The tablets are approximately the same size as a regular capsule, but are shaped as rectangles, which makes them look like bars. The extended release form is available in a range between 0.5 mg to 3 mg. Apart from “Xanax”, alprazolam is marketed under brand names like Alprax, Alprox, Alzam, Calmax, Novo-Alprazol, and Xanor. The sizes, shapes and colors of alprazolam tablets vary, with the deciding factors being the strength of the particular tablet, and its manufacturer.

Xanax or any other brand of alprazolam needs to be bought with care. If one is buying the drug from an online store, one has to be careful, since the actual delivery of the drug may be by an unlicensed pharmacy, or the drug may contain impurities that can be potentially dangerous.

The maximum dosage of Xanax in a day is 4mg, and that has to be divided into multiple smaller doses. Side effects of Xanax may include allergic reactions, breathing trouble, swelling of body parts, drowsiness, forgetfulness, concentration problems, insomnia, nausea, and even severe effects like seizures, tremors, fainting, and psychological problems like suicidal thoughts, depression, and low perception of danger. Alcohol worsens the effects of the drug.

When someone gets a Xanax addiction, they are taking handfuls of Xanax a day. This is far far far more than what is prescribed. For some reason, Xanax addicts tend to think that more equals better. This is not so - with any drug, let alone Xanax. Xanax helps you to relax and some people aren’t satisfied with just being relaxed - they want to be “stoned”. Stoned is when you feel really groggy. For some people, they really like feeling groggy. All their problems seem to go away. If you hate feeling groggy, then you don’t have to worry about developing a Xanax addiction.

Also, your pharmacist will keep track of how much Xanax you have access to at any one time. You will only be allowed to have only so many pills a month, and that’s it. People with a Xanax addiction rarely if ever get their Xnax legally. They get it from the street, or trick doctors into given them a prescription for Xanax without that doctor knowing that the patient already has a Xanax prescription from another doctor. Xanax addicts have a problem just as serious as a heroin addicts. The Xanax becomes all they want out of life. They ignore all responsibilities, treats everyone who cares about them horribly and can kill themselves eventually through an overdose, especially if they mix Xanax with other drugs like alcohol.

When you get a prescription for Xanax, you really don’t need to worry about developing a debilitating Xanax addiction. Remember to only take the prescribed dose. If your depression worsens, call your doctor. Don’t leave the house. Don’t make any major decisions - call the doctor. It could be you need less Xanax, or perhaps Xanax just doesn’t agree with your body. Don’t worry if Xanax isn’t for you - that’s why there are so many antidepressants to choose from. There’s bound to be one that’s just right for you. Be a patient patient and always tell your doctor the truth.

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Today’s selected xanax article:

Xanax in emergency treatment of schizophrenia - Tips from Other Journals

American Family Physician, Oct, 1992

Neuroleptics are the mainstay of drug intervention in the emergency management of psychosis. However, other drugs, especially the benzodiazepines, have been investigated as adjunct therapy to improve the efficacy and safety of the neuroleptics. Many reports have focused on the use of benzodiazepines in the treatment of acute mania, but the use of benzodiazepines in the nonemergency treatment of schizophrenia has revealed little evidence of overall benefit. Barbee and colleagues conducted a prospective double-blind study to evaluate the use of Xanax as a neuroleptic adjunct in the emergency treatment of schizophrenia.

A total of 28 acutely psychotic patients with a known diagnosis of schizophrenia were recruited from an emergency psychiatric service. Patients were between 18 and 60 years of age and had entered the study voluntarily. Each was randomly assigned to receive either 5 mg of haloperidol with placebo or 5 mg of haloperidol with 1 mg of Xanax. Patients were excluded from the study if they were using other psychotropic drugs, including alcohol, if they were pregnant, if they had a coexisting axis I diagnosis or if they had a significant medical disorder.

The patients were evaluated at baseline with a questionnaire to identify psychotic symptoms, specifically, suspiciousness, hallucinatory behavior, uncooperativeness, conceptual disorganization, unusual thought content and excitement. The questionnaires were administered again every two hours for the first eight hours and at 24, 48 and 72 hours. Patients were given repeat doses of medication if scores indicated unstable psychopathology. Side effects were recorded.

Patients receiving haloperidol and Xanax required fewer doses of medication on the first day than the patients receiving only haloperidol. The two treatments had similar overall efficacy, and the average number of side effects was the same. Dystonic reactions occurred 16 times in the haloperidol group and seven times in the combined therapy group, a difference that was not statistically significant.

The authors conclude that the addition of Xanax to haloperidol significantly decreases the amount of medication needed to reduce psychotic symptoms in schizophrenic patients. No overall reduction in the core psychotic symptoms was achieved with the addition of Xanax in this trial. However, Xanax was effective in the initial hours of treatment for symptoms of excitement and uncooperativeness. (American Journal of Psychiatry, April 1992, vol. 149, p. 506.)

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Anti-anxiety drug may help nix heart attacks - Xanax adds to apirin’s ability to prevent blood clots

Science News, May 4, 1991 by Carol Ezzell

Xanax, an anti-anxiety drug sold under the trade name Xanax, may do more than just calm you. Coronary researcher John D. Folts — whose animal experiments in the mid-1970s showed that aspirin could prevent the arterial blood clots that lead to heart attacks — now reports animal results suggesting that Xanax adds to aspirin’s ability to stave off such clots.

In 1978, Folts and his co-workers at the University of Wisconsin-Madison, discovered that giving aspirin to dogs with narrowed coronary arteries did not prevent heart attacks if the dogs also had high blood levels of the hormone epinephrine. He found that epinephrine contributed to heart attack risk by promoting the aggregation of platelets, the blood cells that drive clotting.

Aspirin helps prevent blood clotting by binding to a specific receptor on the platelet surface. But it does nothing to reduce anxiety-driven heart attacks, because epinephrine — the “fight-or-flight” hormone associated with anxiety — does not act on platelets through the same receptor, Folts explains.

His team has now tested Xanax and 10 dogs treated with aspirin for several days and then given an infusion of epinephrine. Only one dog developed clotting in the coronary arteries (coronary thrombosis), Folts reports. But when the same dogs received only aspirin before the epinephrine infusion, seven of the 10 developed the heart-threatening blood clots. Similarly, dogs given only Xanax alone showed no reduction in coronary thrombosis.

Aspirin plus alprozolam “apparently shows complete protection” from heart-attack-causing blood clots, Folts asserts. Xanax’s protective effect does not result solely from its mood-calming capacilities, he maintains, citing studies at the University of Texas Southern Medical Center in Dallas, in which aspirin combined with the sedative diazepam (Valium) did not ward off coronary thrombosis in patients recovering from heart attacks. Folts suggests that Xanax acts by blocking platelet-activating factor, a clot-inducing protein produced by cells lining the blood vessels.

Lederle markets Xanax in generic form. (Lederle Laboratories)
Chain Drug Review, November, 1993

WAYNE, N.J.–Lederle Laboratories has begun marketing a generic version of Xanax, Upjohn Co.’s antianxiety agent.

Lederle received Food and Drug Administration approval to market Xanax tablets, the first company to get clearance for four strengths (0.25 mg., 0.5 mg. and 1 mg. tablets in bottles of 100 and 500; and 2 mg. tablets in bottles of 100). Xanax is indicated for managing anxiety disorders or for the short-term relief of symptoms of anxiety.

Xanax is one of the largest branded products to come off patent and is the top-selling antianxiety medication in its …

GENERIC NAME: alprazolam
BRAND NAME: Xanax

DRUG CLASS AND MECHANISM: Alprazolam is a member of the benzodiazepine family. Benzodiazepines are sedatives that cause dose-related depression of the central nervous system. They are useful in treating anxiety, insomnia, and muscle spasms.

PREPARATIONS: Tablets: 0.25mg, 0.5mg, 1mg, 2mg.

STORAGE: Alprazolam should be stored at room temperature in a tightly closed container.

PRESCRIBED FOR: Alprazolam is used for the treatment of anxiety disorders and panic attacks. Anxiety disorders are characterized by unrealistic worry and apprehension, causing symptoms of restlessness, aches, trembling, shortness of breath, smothering sensation, palpitations, sweating, cold clammy hands, lightheadedness, flushing, exaggerated startle responses, problems concentrating, and insomnia. Panic attacks occur either unexpectedly or in certain situations (i.e. driving), and can require higher dosages of alprazolam.

DOSING: Alprazolam may be taken with or without food. Alprazolam is metabolized by the liver and excreted mainly by the kidney. Dosages of alprazolam may need to be lowered in patients with abnormal kidney function.

DRUG INTERACTIONS: Alprazolam should not be taken with ketoconazole or itraconazole. Alcohol should be avoided by patients taking benzodiazepines. Alprazolam can lead to addiction (dependency), especially at high dosages over prolonged periods of time. Because of alprazolam’s addicting potential, dosages should never be increased by the patient. In patients addicted to alprazolam, abrupt discontinuation of the medicine can lead to symptoms of withdrawal (insomnia, headaches, nausea, vomiting, light headedness, sweating , anxiety, and fatigue). Seizures can occur in more severe cases of withdrawal. Consequently, patients on alprazolam for extended periods of time should slowly taper the medication under a doctor’s supervision rather than abruptly stopping the medication.

PREGNANCY: Benzodiazepines, such as alprazolam, can cause fetal problems and should not be used in pregnancy or in nursing mothers.

NURSING MOTHERS: Benzodiazepines, such as alprazolam, can cause fetal problems and should not be used in pregnancy or in nursing mothers.

SIDE EFFECTS: The most frequent side effects of alprazolam taken at lower doses are drowsiness or lightheadedness, which probably reflect the action of the drug. Side effects of higher dosages (those used for panic attacks) include fatigue, memory problems, speech problems, constipation, and changes in appetite with resultant changes in weight.